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California Regional Multiple Listing Service

The multiple listing data appearing on this website, or contained in reports produced therefrom, is owned and copyrighted by California Regional Multiple Listing Service, Inc. ("CRMLS") and is protected by all applicable copyright laws. Information provided is for viewer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties the viewer may be interested in purchasing. All listing data, including but not limited to square footage and lot size is believed to be accurate, but the listing Agent, listing Broker and CRMLS and its affiliates do not warrant or guarantee such accuracy. The viewer should independently verify the listed data prior to making any decisions based on such information by personal inspection and/or contacting a real estate professional.

Based on information from California Regional Multiple Listing Service, Inc. as of the most recent time synced and /or other sources. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information

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Peninsula Biotech Capital

About South San Francisco, CA

Welcome to South San Francisco, the San Mateo County "birthplace of biotechnology" set between San Bruno Mountain and the bay, minutes from downtown San Francisco and SFO.

South San Francisco sits in northern San Mateo County on the bay side of the San Francisco Peninsula, separated from San Francisco itself by the city of Daly City and Brisbane to the north. Although the two share a name, South San Francisco is an independent, incorporated city with its own identity, economy, and civic history. Founded amid the industrial growth of the early twentieth century, the city was long known for its stockyards, steel mills, and manufacturing plants, a heritage commemorated by the giant white letters reading "South San Francisco The Industrial City" that have stood on the hillside since the 1920s. That industrial foundation evolved into one of the most significant life-science economies in the world. The founding of Genentech in 1976 marked the beginning of the biotechnology industry, and South San Francisco has since grown into a dense cluster of more than 250 biotech and pharmaceutical companies occupying millions of square feet of laboratory and office space. The city describes itself as the birthplace of biotechnology, and its workforce is shaped by scientists, researchers, and the supporting professional community drawn to the East of 101 corridor. Residentially, South San Francisco is a diverse, family-oriented city of roughly 65,000 people. Its neighborhoods climb the lower slopes of Sign Hill and San Bruno Mountain, with many homes enjoying views across the bay toward San Francisco and the East Bay. The population includes a large Filipino American community along with long-established immigrant communities, contributing to a rich mix of restaurants, churches, and cultural institutions along the Grand Avenue corridor and downtown. Location is one of the city's defining advantages. It sits directly between two major freeways, U.S. Highway 101 and Interstate 280, is served by both BART and Caltrain rail lines, and lies immediately adjacent to San Francisco International Airport. This connectivity, combined with the city's biotech base and its relative value within the expensive Peninsula market, makes South San Francisco a practical and increasingly sought-after address for commuters and life-science workers alike.

Population 64,583
County San Mateo
Active Listings 84

Frequently Asked Questions

What county is South San Francisco in?

South San Francisco is in San Mateo County, California, on the bay side of the San Francisco Peninsula. It sits just south of San Francisco, separated from it by Daly City and Brisbane, and is an independent incorporated city rather than a neighborhood of San Francisco itself.

What is South San Francisco known for?

South San Francisco is known as the birthplace of biotechnology. Genentech was founded there in 1976, and the city has since grown into one of the world's largest biotech clusters, home to more than 250 life-science companies. It is also known for its historic hillside sign reading 'South San Francisco The Industrial City,' which reflects its earlier manufacturing and stockyard heritage.

How do people commute from South San Francisco to San Francisco?

South San Francisco has a BART station offering direct rail service to downtown San Francisco, and a Caltrain station with service between San Francisco and San Jose. U.S. Highway 101 and Interstate 280 provide freeway access by car, and SamTrans buses serve local routes. San Francisco International Airport is immediately adjacent and reachable in minutes by BART or car.

What school district serves South San Francisco?

The South San Francisco Unified School District serves the city, operating 17 schools with roughly 7,700 students. The district also covers a small portion of San Bruno and the Serramonte area of Daly City. It includes multiple elementary schools and South San Francisco and El Camino high schools.

What is the population of South San Francisco?

South San Francisco has a population of roughly 65,000 residents. It is a diverse, family-oriented city with a large Filipino American community and a workforce strongly shaped by the life-science industry concentrated along the East of 101 corridor.

City Guide

About South San Francisco

Real Estate & Housing

South San Francisco's housing stock reflects its mid-century industrial growth and its more recent role as a Bay Area employment center. The hillside neighborhoods are dominated by single-family homes built largely from the 1940s through the 1970s, including ranch-style and split-level houses, many on modest lots with bay views. The flatter areas near downtown and the transit corridors offer a growing supply of condominiums, townhomes, and apartment buildings, including newer development near the BART station. Neighborhoods such as Westborough, Sunshine Gardens, Buri Buri, and Serra Highlands each carry distinct mid-century characters. The city's combination of commuter rail access, proximity to San Francisco, and a major local employment base sustains consistent housing demand across both the hillside and valley areas.

Neighborhoods

South San Francisco is organized around a downtown core and a series of hillside and valley neighborhoods. Westborough, on the city's south side, is a sizable planned residential district known for its parks and schools. Sunshine Gardens and Buri Buri occupy the central valley with mid-century single-family homes near shopping and transit. Serra Highlands and the neighborhoods climbing Sign Hill offer elevated lots and views of the bay and San Bruno Mountain. On the east side, Old Town and the Grand Avenue corridor anchor the city's downtown with civic buildings, retail, and dining. Smaller pockets such as Paradise Valley, Francisco Terrace, and Mayfair Village round out a city whose neighborhoods are generally compact, walkable, and closely connected to the freeways and rail lines.

Lifestyle in South San Francisco

South San Francisco blends a hardworking industrial legacy with a family-centered, culturally rich present. The city's diversity is central to its character, with a prominent Filipino American community and a broad mix of residents that is reflected in the restaurants, bakeries, and markets along Grand Avenue and throughout town. The biotech corridor brings a steady stream of scientists and professionals, while long-time residents maintain deep roots in the city's civic, religious, and community organizations. Downtown hosts civic events and gatherings, and the city's compact scale means most neighborhoods are within a short drive of shopping, dining, and schools. Life here moves at a slightly slower pace than San Francisco across the hill, yet remains fully plugged into the regional economy.

Schools & Education

Public education in South San Francisco is provided by the South San Francisco Unified School District, which operates 17 schools serving roughly 7,700 students. The district covers the city of South San Francisco along with a small portion of neighboring San Bruno and the Serramonte area of Daly City, and includes multiple elementary schools, middle schools, and South San Francisco and El Camino high schools. The district's elementary campuses include Buri Buri, Junipero Serra, Los Cerritos, Martin, Monte Verde, and Ponderosa, among others. For higher education, nearby Skyline College in San Bruno and the broader San Mateo County Community College District offer convenient options, while San Francisco's universities are a short BART ride away.

Getting Around

South San Francisco offers some of the strongest transportation access on the Peninsula. A BART station at the city's center provides direct rail service to San Francisco, the East Bay, and San Francisco International Airport, while Caltrain stops in South San Francisco with service between San Francisco and San Jose. SamTrans buses cover local routes, and U.S. Highway 101 and Interstate 280 run along the city's eastern and western flanks. San Francisco International Airport lies immediately south, reachable in minutes by car or BART. This layered network gives residents car-free commuting options and makes the city a convenient base for workers across the Bay Area's biotech, tech, and service economies.

Parks & Recreation

Outdoor recreation centers on Sign Hill and San Bruno Mountain, the two ridgelines that frame the city. Sign Hill Park preserves 65 acres of grassland and scrub and offers a loop trail leading to the landmark hillside sign, with sweeping views over the bay. The larger San Bruno Mountain State and County Park, directly to the north, provides extensive hiking and ridge-top vistas of the entire Bay Area. Along the bayfront, the San Francisco Bay Trail offers walking and cycling with water views, and city parks such as Orange Memorial Park provide sports fields, playgrounds, and community facilities. The combination of hillside trails, bayfront paths, and easy freeway access to regional parks makes the city unusually well connected to the outdoors.

MARKET SNAPSHOT

The Market at a Glance

How homes have been selling here over the last 90 days.

home_work New This Week 5
Went Under Contract 0
trending_down Price Reductions 0
payments Median Sale Price $1,277,000 +11.0%
square_foot Price per Sq Ft $967
schedule Avg Days on Market 9
sell Homes Sold 22
percent Sale-to-List Ratio 109.0%
inventory_2 Months of Inventory 8.2

Price & Sales History

Market data reflects closed sales over the last 90 days and is provided for informational purposes.

For sale

Houses in South San Francisco, CA

Handpicked properties hitting the scene in your area.

Address Not Shown ComingSoon
$837,000,000
Address Not ShownSan Diego, CA 92117
  • 2 bd
  • 1.5 ba
  • 1040 sqft
  • Built 1954
  • 260020737SD
Keller Williams San Diego Metro
11201 Chalon Road For Sale
$400,000,000
11201 Chalon RoadLos Angeles, CA 90049
  • 39 bd
  • 54.5 ba
  • 70000 sqft
  • Built 2018
  • 26814383
The Beverly Hills Estates
607 Siena Way For Sale
$135,000,000
607 Siena WayLos Angeles, CA 90077
  • 8 bd
  • 15 ba
  • 26868903
The Beverly Hills Estates
1261 Angelo Drive For Sale
$135,000,000
1261 Angelo DriveBeverly Hills, CA 90210
  • 16 bd
  • 21.5 ba
  • 50000 sqft
  • Built 2012
  • 24449959
Westside Estate Agency Inc.
7661 Curson Terrace For Sale
$125,000,000
7661 Curson TerraceLos Angeles, CA 90046
  • 7 bd
  • 12 ba
  • 22000 sqft
  • Built 2025
  • 26841395
The Beverly Hills Estates
100 Rockledge Road For Sale
$112,000,000
100 Rockledge RoadLaguna Beach, CA 92651
  • 8 bd
  • 13 ba
  • 14434 sqft
  • Built 1974
  • LG26161709
Livel Real Estate
1200 Bel Air Road For Sale
$99,950,000
1200 Bel Air RoadLos Angeles, CA 90077
  • 12 bd
  • 17 ba
  • Built 2021
  • 26838975
Compass
729 Bel Air Road For Sale
$95,000,000
729 Bel Air RoadLos Angeles, CA 90077
  • 9 bd
  • 16 ba
  • 18784 sqft
  • Built 1972
  • 25497825
Westside Estate Agency Inc.
32229 Coast Hwy For Sale
$95,000,000
32229 Coast HwyLaguna Beach, CA 92651
  • 10 bd
  • 6.5 ba
  • 4900 sqft
  • Built 1930
  • NP26126003
Compass
28824 Cliffside Drive For Sale
$90,000,000
28824 Cliffside DriveMalibu, CA 90265
  • 9 bd
  • 14 ba
  • 17701 sqft
  • Built 1991
  • 26852035
Compass
26848 Pacific Coast Highway For Sale
$88,000,000
26848 Pacific Coast HighwayMalibu, CA 90265
  • 7 bd
  • 9.5 ba
  • 15430 sqft
  • Built 2000
  • 26839373
Compass
1900 Spindrift Dr For Sale
$87,500,000
1900 Spindrift DrLa Jolla, CA 92037
  • 10 bd
  • 15.5 ba
  • 12981 sqft
  • Built 2015
  • 260013034SD
Compass

For sale

Townhomes in South San Francisco, CA

Handpicked properties hitting the scene in your area.

1504 W Oceanfront #5 For Sale
$27,950,000
1504 W Oceanfront #5Newport Beach, CA 92663
  • 6 bd
  • 6 ba
  • 7609 sqft
  • Built 1962
  • NP26015959
Pacific Sotheby's Int'l Realty
921 Gaviota Drive For Sale
$16,995,000
921 Gaviota DriveLaguna Beach, CA 92651
  • 7 bd
  • 6.75 ba
  • 6050 sqft
  • Built 1990
  • LG26049856
Livel Real Estate
921 Gaviota Drive Active
$16,995,000
921 Gaviota DriveLaguna Beach, CA 92651
  • Built 1990
  • LG26152380
Livel Real Estate
33040 Rancho Vista Drive Active
$15,885,000
33040 Rancho Vista DriveCathedral City, CA 92234
  • Built 2026
  • OC26148726
Tri-Star Realty
1001 Silverado Trail South Active
$15,500,000
1001 Silverado Trail SouthSt Helena, CA 94574
  • Built 1999
  • OC25034490
Coldwell Banker Realty
650 S Lake Ave Active
$14,380,000
650 S Lake AvePasadena, CA 91106
  • Built 2010
  • TR26122576
Graceland Investment, Inc.
2120 The Strand For Sale
$13,999,999
2120 The StrandManhattan Beach, CA 90266
  • 17 bd
  • 15 ba
  • 8880 sqft
  • Built 1972
  • SB26098240
S C Real Estate
920 The Strand For Sale
$13,950,000
920 The StrandManhattan Beach, CA 90266
  • 6 bd
  • 5 ba
  • 3083 sqft
  • Built 1957
  • OC26043254
Lima Real Estate Group
7246 Sharon Drive For Sale
$13,500,000
7246 Sharon DriveSan Jose, CA 95129
  • 5 bd
  • 4 ba
  • 2400 sqft
  • Built 2026
  • ML82054389
Lexicon Homes
618 W Route 66 Active
$12,295,000
618 W Route 66Glendora, CA 91740
  • Built 1962
  • CV26143474
MARCUS & MILLICHAP
5120 E Livingston Drive Active
$12,200,000
5120 E Livingston DriveLong Beach, CA 90803
  • Built 1943
  • PW25065019
Keller Williams Realty Downey
1800 Atascadero Road For Sale
$12,000,000
1800 Atascadero RoadMorro Bay, CA 93442
  • 4 bd
  • 2500 sqft
  • Built 1990
  • NS25061509
JoAnn Wall, Broker

For sale

Condos in South San Francisco, CA

Handpicked properties hitting the scene in your area.

9900 S Santa Monica Boulevard #PHE For Sale
$35,000,000
9900 S Santa Monica Boulevard #PHEBeverly Hills, CA 90212
  • 3 bd
  • 4 ba
  • 5818 sqft
  • Built 2024
  • 26672327
Compass
183 Carnation Avenue For Sale
$31,995,000
183 Carnation AvenueCorona del Mar, CA 92625
  • 2 bd
  • 3.5 ba
  • 3553 sqft
  • Built 2021
  • NP26153365
Coldwell Banker Realty
225 Canon Drive #7C For Sale
$23,475,000
225 Canon Drive #7CBeverly Hills, CA 90210
  • 4 bd
  • 4.5 ba
  • 4695 sqft
  • Built 2008
  • 26667489
ORES Realty
225 Canon Drive #7D For Sale
$22,300,000
225 Canon Drive #7DBeverly Hills, CA 90210
  • 4 bd
  • 4.5 ba
  • 4957 sqft
  • Built 2008
  • 26839981
Resident Group
1 Limasol 3107, Cyprus For Sale
$21,245,000
1 Limasol 3107, CyprusCA
  • 6 bd
  • 5 ba
  • 9688 sqft
  • 26657173
Berkshire Hathaway HomeServices California Properties
1 Stickley Drive For Sale
$19,995,000
1 Stickley DriveLaguna Beach, CA 92651
  • 3 bd
  • 3.5 ba
  • 2900 sqft
  • Built 2003
  • LG25282175
The Agency
602 Ave Jose Banus, Marbella For Sale
$18,999,999
602 Ave Jose Banus, MarbellaOther, OS 29660
  • 7 bd
  • 7.5 ba
  • 10602 sqft
  • Built 1987
  • PW26034454
Harwil Real Estate
829 Coast Blvd S For Sale
$15,400,000
829 Coast Blvd SLa Jolla, CA 92037
  • 4 bd
  • 5.5 ba
  • 5347 sqft
  • Built 2026
  • 260018314SD
Compass
835 Coast For Sale
$15,400,000
835 CoastLa Jolla, CA 92037
  • 4 bd
  • 5.5 ba
  • 4830 sqft
  • Built 2026
  • 260018323SD
Compass
837 Coast blvd S Pending
$15,400,000
837 Coast blvd SLa Jolla, CA 92037
  • 4 bd
  • 5.5 ba
  • 5476 sqft
  • Built 2026
  • 260018312SD
Compass
10727 Wilshire Boulevard #PH2 For Sale
$13,995,000
10727 Wilshire Boulevard #PH2Los Angeles, CA 90024
  • 3 bd
  • 4 ba
  • 5540 sqft
  • Built 2001
  • 26850463
The Beverly Hills Estates
9200 Wilshire Boulevard #PH1E For Sale
$13,500,000
9200 Wilshire Boulevard #PH1EBeverly Hills, CA 90212
  • 3 bd
  • 3.5 ba
  • 3440 sqft
  • Built 2022
  • 26830665
Compass

Zip Codes

BROWSE BY ZIP

Browse listings by postal code in this area.

039 homes for saleMedian sale$295K1 sale in the last 90 days
0000021 homes for saleMedian sale$370KPer sq ft$199 sales in the last 90 days
100231 home for saleMedian sale$1M2 sales in the last 90 days
111111 home for saleMedian sale$295K
123451 home for saleMedian sale$295K
218501 home for saleMedian sale$145KPer sq ft$1275 sales in the last 90 days
227132 homes for saleMedian sale$565KPer sq ft$2744 sales in the last 90 days
227401 home for saleMedian sale$315KPer sq ft$2643 sales in the last 90 days
483121 home for saleMedian sale$317KPer sq ft$166133 sales in the last 90 days
759641 home for saleMedian sale$205KPer sq ft$1151 sale in the last 90 days
760631 home for saleMedian sale$495KPer sq ft$190254 sales in the last 90 days
777601 home for saleMedian sale$129.4KPer sq ft$3101 sale in the last 90 days
View All Zip Codes
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23 Shasta Court For Sale
$2,099,000
23 Shasta CourtSouth San Francisco, CA 94080
  • 4 bd
  • 3.5 ba
  • 2980 sqft
  • Built 1959
  • ML82058781
Christie's International Real Estate Sereno
169 Cymbidium Circle For Sale
$1,398,000
169 Cymbidium CircleSouth San Francisco, CA 94080
  • 3 bd
  • 2.5 ba
  • 1610 sqft
  • Built 2000
  • ML82058561
Compass
157 A STREET For Sale
$939,000
157 A STREETSouth San Francisco, CA 94080
  • 2 bd
  • 1 ba
  • 860 sqft
  • Built 1941
  • ML82058178
Berkshire Hathaway HomeServices DrysdaleProperties
129 Drake Ave For Sale
$1,090,000
129 Drake AveSouth San Francisco, CA 94080
  • 3 bd
  • 2 ba
  • 1126 sqft
  • Built 1941
  • 41145857
Compass
9 West Way For Rent
$6,900
9 West WaySouth San Francisco, CA 94080
  • 4 bd
  • 3.5 ba
  • 2780 sqft
  • Built 2003
  • ML82058335
Compass
2200 Delvin Way For Sale
$1,598,000
2200 Delvin WaySouth San Francisco, CA 94080
  • 4 bd
  • 3 ba
  • 2230 sqft
  • Built 1965
  • ML82057612
KW Advisors
3755 Radburn Drive For Rent
$4,250
3755 Radburn DriveSouth San Francisco, CA 94080
  • 3 bd
  • 1.5 ba
  • 1115 sqft
  • Built 1971
  • 26871963
CONTEXTRE
107 Mulberry Avenue For Sale
$1,200,000
107 Mulberry AvenueSouth San Francisco, CA 94080
  • 3 bd
  • 1 ba
  • 980 sqft
  • Built 1944
  • ML82057159
Franco Real Estate Group
3550 Carter Drive #41 For Rent
$3,450
3550 Carter Drive #41South San Francisco, CA 94080
  • 2 bd
  • 1.5 ba
  • 877 sqft
  • Built 1979
  • ML82057239
Intero Real Estate Services
141 Pecks Lane For Sale
$849,000
141 Pecks LaneSouth San Francisco, CA 94080
  • 3 bd
  • 1 ba
  • 870 sqft
  • Built 1955
  • ML82056173
Omarshall, Inc
227 Rockwood Drive For Sale
$1,299,888
227 Rockwood DriveSouth San Francisco, CA 94080
  • 3 bd
  • 2 ba
  • 1390 sqft
  • Built 1946
  • ML82055951
Metro Realty Pros
811 Marcie Circle For Sale
$498,000
811 Marcie CircleSouth San Francisco, CA 94080
  • 1 bd
  • 1 ba
  • 673 sqft
  • Built 1986
  • ML82053892
Coldwell Banker Realty
523 Baden Avenue For Sale
$975,000
523 Baden AvenueSouth San Francisco, CA 94080
  • 3 bd
  • 2 ba
  • 970 sqft
  • Built 1910
  • ML82055913
Kenny Realty
770 Miller Avenue For Sale
$1,749,000
770 Miller AvenueSouth San Francisco, CA 94080
  • 3 bd
  • 3 ba
  • 2360 sqft
  • Built 1962
  • ML82052271
Intero Real Estate Services
889 McLellan Drive #210 For Sale
$1,385,000
889 McLellan Drive #210South San Francisco, CA 94080
  • 3 bd
  • 2 ba
  • 1635 sqft
  • Built 2026
  • ML82052287
Peter Suen, Broker
2712 Meath Drive For Sale
$849,999
2712 Meath DriveSouth San Francisco, CA 94080
  • 3 bd
  • 1.5 ba
  • 1200 sqft
  • Built 1973
  • ML82051980
Clearstory Real Estate
889 McLellan Drive #206 For Sale
$919,000
889 McLellan Drive #206South San Francisco, CA 94080
  • 2 bd
  • 2 ba
  • 1011 sqft
  • Built 2026
  • ML82051562
Peter Suen, Broker
648 Newman Drive For Sale
$1,680,000
648 Newman DriveSouth San Francisco, CA 94080
  • 3 bd
  • 3 ba
  • 1765 sqft
  • Built 1956
  • ML82049164
Green Banker Realty
889 McLellan Drive #205 For Sale
$799,000
889 McLellan Drive #205South San Francisco, CA 94080
  • 1 bd
  • 1 ba
  • 806 sqft
  • Built 2026
  • ML82046471
Peter Suen, Broker
20 Maple Avenue For Sale
$899,000
20 Maple AvenueSouth San Francisco, CA 94080
  • 2 bd
  • 1 ba
  • 900 sqft
  • Built 1917
  • ML82045331
KW Advisors
2637 Bantry Court For Sale
$1,229,000
2637 Bantry CourtSouth San Francisco, CA 94080
  • 3 bd
  • 3.5 ba
  • 1536 sqft
  • Built 2020
  • ML82043394
Berkshire Hathaway HomeServices DrysdaleProperties
21

Nearby Cities

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  • San Francisco7.1 mi158 Listings
  • Burlingame6.3 mi35 Listings
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  • Alameda12 mi92 Listings
  • El Granada11 mi23 Listings

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Contact us

Holly Kauffman

(310) 345-0165

perfectfamilyhomes@gmail.com

Redondo - Pacific Coast Highway

200 South Pacific Coast Hwy Redondo Beach, CA 90277 CA, Redondo Beach 90277

  • (310) 543-3536

Redondo - South Catalina

1716 South Catalina Ave Redondo Beach, CA 90277

  • (310) 543-3536

El Segundo - Main Street

431 Main Street El Segundo, CA 90245

  • (310) 543-3536